49ERS KEYS TO VICTORY: Can Kyle Shanahan and Brock Purdy SOLVE Seattle Seahawks Defense?

San Francisco 49ers face a defining early test against the Seattle Seahawks—can Brock Purdy outduel Sam Darnold and flip the script on Mike Macdonald’s stingy defense? Explosive plays might be the difference-maker, as the 49ers look to recapture past shootout magic while overcoming recent injuries to key targets like Mike Evans and Deebo Samuel.

Brian Peacock and Eric Crocker break down Shanahan vs. Macdonald Part 6, revisit the history of this coaching chess match, and spotlight players returning from injury, including Mykel Williams. The conversation covers whether Christian McCaffrey and Kaelin Black can find running lanes against Byron Murphy and Leonard Williams, the battle for best QB in the NFC West, and how the Niners’ offensive line holds up under pressure. Can San Francisco’s defense force turnovers and make the Seahawks one-dimensional? Discover the keys to victory and what this clash reveals about both NFC West contenders.

San Francisco 49ers fans are treated to daily news and analysis with Locked On 49ers, hosted by football analyst Brian Peacock and former NFL/AFL cornerback Eric Crocker.

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