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Welcome to a packed prediction edition of The Audible! Bruce Feldman, Stewart Mandel, and Ralph Russo deliver their official game breakdowns, betting lines, and against-the-spread predictions for an absolute blockbuster slate of Week 6 college football action.
The crew kicks off the show diving straight into a heated debate surrounding the controversy in the latest AP Top 25 rankings. Stew details why sticky preseason expectations are keeping teams like USC and Texas Tech overranked, while Bruce questions Utah's true standing on the ballot. Ralph takes you completely inside his official voter process to explain the absolute nightmare of trying to slot the middle tier from numbers 8 through 12. Ultimately, the guys break down why the current rankings are structured the way they are and who got left out entirely.
From there, the focus shifts to Lincoln for an in-depth look at undefeated Nebraska ahead of their massive Big Ten clash. Can Matt Rhule and the 5-0 Cornhuskers finally pick up a signature win over a ranked opponent, or will his grueling 20-game losing streak against ranked teams continue? This 5-0 start is Nebraska's best opening to a season since 2016, driven by a dominant defense and an offense that has outscored opponents by a massive 218-90 margin. Ralph breaks down why Nebraska fans aren't treating this as a do-or-die crisis for Rhule, contrasting it against the overwhelming, program-crushing pressure teams like Penn State endured in similar spots last season.
To wrap up the show, the guys drop their definitive straight-up and against-the-spread picks for the biggest matchups on the board:
🏈 No. 7 Indiana at Nebraska (-7.5)
Will the high-flying Hoosiers stay perfect in Lincoln, or can the Huskers' defense choke out Curt Cignetti's offense? The crew is completely split on whether the Huskers can cover the 7.5-point spread on their home turf.
🏈 No. 2 Georgia at No. 6 Alabama (-1.5)
For the ninth time since 2017, college football's premier heavyweight rivalry meets as a pair of Top 10 teams. Does Kalen DeBoer pick up his first signature SEC win in Tuscaloosa, or does Georgia defend its playoff standing on the road?
🏈 No. 1 Texas (-8.5) at Oklahoma
The Red River Rivalry takes center stage in the SEC. The top-ranked Longhorns are laying more than a touchdown against a dangerous Sooners squad in a hostile environment—find out who the guys expect to win the Golden Hat.
🏈 No. 21 UCLA at No. 13 Oregon (-11.5)
A massive Big Ten coastal clash under the lights. Can the Bruins keep it close and cover the large double-digit spread on the road, or will the Ducks roll comfortably inside Autzen Stadium?
🔥 Upset Picks of the Week
The crew uncovers the best betting value on the board and reveals their locks for the most likely outright underdogs to win in Week 6, featuring crucial spreads on Washington State, Houston, Purdue, and Florida State.
Follow the Crew on X:
🔹 Stewart Mandel: @slmandel
🔹 Bruce Feldman: @BruceFeldmanCFB
🔹 Ralph Russo: @ralphDrussoATH
🔹 The Audible: @audible.show
#CollegeFootball #Week6Picks #NebraskaFootball #IndianaFootball #AlabamaVsGeorgia #TexasLonghorns #OklahomaSooners #OregonDucks #APTop25 #TheAudible #CFBPlayoff #AgainstTheSpread #CollegeFootballPredictions
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"Matt Rhule & Nebraska’s Ultimate Litmus Test vs. Indiana + Week 6 Picks" is an episode of The Audible with Stew, Bruce & Ralph: A show about college football. Runtime 58 min. Published October 6, 2026. Hit play above to stream it here, or open the free Spot Sports app for background play and offline downloads.