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Week 10 of the college football season is loaded with massive matchups, playoff implications, and intriguing betting opportunities! Tim Murray and Matt Youmans return for another edition of the VSiN College Football Betting Podcast to break down the biggest games on the Week 10 schedule.
The guys open with a highly anticipated showdown between No. 1 Miami and No. 11 Notre Dame in South Bend. With Malachi Toney sidelined, can the Fighting Irish take advantage of their opportunity to strengthen their College Football Playoff chances? They also break down Georgia vs. Ole Miss, Alabama vs. LSU, Texas vs. Missouri, BYU vs. Utah, and Kentucky vs. Tennessee.
The conversation continues with a loaded slate of intriguing matchups, including Ohio State vs. Oregon, Minnesota vs. UCLA, Florida vs. Oklahoma, Michigan vs. Michigan State, and several late-night games out West.
Tim and Matt also examine key injuries, quarterback situations, coaching changes, revenge spots, scheduling concerns, and the latest College Football Playoff picture. Plus, they discuss Friday night opportunities, Mountain West matchups, and their favorite angles from an action-packed Week 10.
Chapters of discussion include:
Notre Dame vs. Miami: Malachi Toney's absence and the playoff implications
Georgia vs. Ole Miss: Can Kirby Smart get revenge?
Alabama vs. LSU: Breaking down the Death Valley showdown
Texas vs. Missouri: Can the Tigers pull off the upset?
BYU vs. Utah: Breaking down the Holy War
Kentucky vs. Tennessee
Ohio State vs. Oregon: A critical playoff elimination game
Minnesota vs. UCLA and Florida vs. Oklahoma
Michigan vs. Michigan State
Fresno State vs. Utah State and Hawaii vs. UTEP
UNLV vs. Wyoming and other late-night matchups
Friday night football and additional Week 10 betting analysis
Subscribe to the VSiN College Football Betting Podcast for weekly college football analysis, betting insights, and expert opinions from Tim Murray and Matt Youmans.
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College Football Week 10 Preview: Notre Dame vs. Miami, LSU vs. Alabama & CFP Rankings w/ Wes Reynolds & Brett Ciancia (@picksixpreviews)
Listen guide
"Week 10 Betting Preview & Best Bets" is an episode of VSiN College Football Betting Podcast. Runtime 1 hr 10 min. Published November 5, 2026. Hit play above to stream it here, or open the free Spot Sports app for background play and offline downloads.