College Football Week 10 Picks: Miami-Notre Dame, Holy War & The Biggest Saturday In A Generation

College Football Week 10 might be the biggest weekend of the entire 2026 season. Seven ranked matchups, massive College Football Playoff implications, and a Saturday schedule that barely gives us a chance to catch our breath. We're making our picks for all of it.

We start with the Holy War between BYU and Utah, then work our way through Texas-Missouri, Alabama-LSU, Oregon-Ohio State and Kentucky-Tennessee. Can Alabama's offense survive a trip to Death Valley? Is Oregon ready to spring an upset in Columbus? And can Kentucky keep finding ways to win?

Then come two monster night games. Georgia visits Ole Miss for a showdown with Trinidad Chambliss, while No. 1 Miami travels to Notre Dame for the latest installment of Catholics vs. Convicts. With the Irish facing a potentially defining moment for their playoff hopes, there's plenty to unpack before we make our predictions.

Plus, we react to the first College Football Playoff rankings, tackle the rest of the weekend's schedule with our Quadfathers picks, spotlight some under-the-radar matchups, and more.

And we're giving away a $500 Delta Air Lines gift card in this week's Run the Board pick'em contest.

Timecodes

0:00:00 - Intro & Saturday Nickname
0:07:03 - College Football Playoff Rankings
00:17:32 - BYU vs Utah
00:26:08 - Texas vs Missouri
00:32:51 - Alabama vs LSU
00:40:11 - Oregon vs Ohio State
00:47:19 - Kentucky vs Tennessee
00:53:24 - Georgia vs Ole Miss
00:59:10 - Miami vs Notre Dame
01:10:10 - Early Quad
01:14:48 - Afternoon Quad
01:18:40 - Night Quad
01:22:52 - Under The Radar Games
01:28:30 - Pat League Lightning Round

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