The #22 Cardinals, in an early ACC conference game, defeated the Tigers, 65-54. The difference in the game was that Louisville made 14 of 15 free throws while Clemson was just 4-15 from the charity stripe. Laura Ziegler led the Cardinals with 17 points and 10 rebounds. Tajianna Roberts had 12 points, four assists, and two steals. Clemson's leading scorer was Rusne Augustinaite with 17 points. Mia Moore finished the game with 11 points, eight rebounds, and five assists.