The St. Louis Blues fell to the Columbus Blue Jackets 4-1 on Septemeber 21, 2025, in the second leg of a preseason opening weekend back-to-back for the Blues. The lone St. Louis goal was scored by Nikita Alexandrov and assisted by Justin Carbonneau and Milan Lucic, and goaltenders Joel Hofer and Vadim Zherenko split time in net.